The Effect of Extract Powder from Fresh and Black Garlic on Main Components in Serum and Organs of Streptozotocin-Induced Diabetic Rats

In this study, we examined the biological activity and synergistic effects of an extract powder of 1%
and 3%, each fresh (FGP) and black garlic (BGP) in streptozotocin-induced diabetic rats. Blood glucose
content was significantly lower in FGP and BGP groups than control group. Glycosylated Hb was significantly
higher in streptozotocin induced diabetic control group than normal group, but significantly
lower in FGP and BGP groups. Total cholesterol content of the FGP and BGP groups were lower than
control group, but not shown the significant difference between garlic fed groups. HDL-cholesterol
concentrations of the FGP and BGP fed groups were significantly higher than control group, except
of 1% BGP group. LDL and VLDL-cholesterol contents were significantly lower in 3% FGP group, and
the same tendency atherogenic index and cardiac risk factor. GOT, GPT, and γ-GTP activity of serum
were lower in FGP and BGP fed groups than control group. Glycogen contents in liver significantly
higher than control group, and has not significantly difference between normal group. TBARS content
was no significantly difference in the liver and serum, but in the kidney, 3% FPG and BGP fed groups
were significantly lower than other experimental group. DPPH radical scavenging activity of liver has
not significant difference among experimental groups, but activity was higher garlic extract powder
fed groups in serum and kidney. These results indicate that dietary supplements of fresh and black
garlic extract powder was contributed to lower of blood glucose, loss prevention of glycogen in liver
and improve of lipid metabolism.

Key words : Streptozotocin, garlic extract, diabetes, blood glucose, DPPH radical scavenging activity